Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota.

ABSTRACT:

Background

Insulin resistance precedes metabolic syndrome which increases the risk of type 2 diabetes and cardiovascular disease. However, there is a lack of safe and long-lasting methods for the prevention and treatment of insulin resistance. Gut microbiota dysbiosis can lead to insulin resistance and associated glucose and lipid metabolic dysfunction. Thus, the role of gut microbiota in metabolic diseases has garnered growing interest. Curcumin, the active ingredient of tropical plant Curcuma longa, has excellent prospects for the prevention and treatment of metabolic diseases. However, due to the extremely low bioavailability of curcumin, the mechanisms by which curcumin increases insulin sensitivity remains to be elucidated. This study aimed to elucidate the role of gut microbi

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC9644619 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature