Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis.

ABSTRACT: Accumulation of lipid-laden foam cells in the arterial wall plays a central role in atherosclerotic lesion development, plaque progression, and late-stage complications of atherosclerosis. However, there are still fundamental gaps in our knowledge of the underlying mechanisms leading to foam cell formation in atherosclerotic arteries. Here, we investigated the role of receptor-independent macropinocytosis in arterial lipid accumulation and pathogenesis of atherosclerosis. Genetic inhibition of fluid-phase macropinocytosis in myeloid cells (LysMCre⁺ Nhe1^fl/fl) and repurposing of a Food and Drug Administration (FDA)-approved drug that inhibits macrophage macropinocytosis substantially decreased atherosclerotic lesion development in low-density lipoprotein (LDL) r

SUBMITTER: Lin HP 

PROVIDER: S-EPMC9645012 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature