Cellular Heterogeneity and Molecular Reprogramming of the Host Response during Influenza Acute Lung Injury.

ABSTRACT: An exuberant host response contributes to influenza A virus (IAV) (or influenza)-mediated lung injury. However, despite significant information on the host response to IAV, the cellular framework and molecular interactions that dictate the development of acute injury in IAV-infected lungs remain incompletely understood. We performed an unbiased single-cell RNA sequencing (scRNAseq) analysis to examine the cellular heterogeneity and regulation of host responses in the IAV model of acute lung injury. At the cellular level, IAV infection promoted the overwhelming recruitment of monocytes that exhibited the cell differentiation trajectory to monocyte-derived macrophages. Together, monocytes and monocyte-derived myeloid cells constituted over 50% of the total immune cells in IAV-infected lungs.

SUBMITTER: Guo K 

PROVIDER: S-EPMC9645213 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature