Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics.

ABSTRACT:

Abbreviations

CE-SDS: capillary electrophoresis sodium dodecyl sulfate; DSC: differential scanning calorimetry; FACS: fluorescence-activated cell sorting; FSA: full-sized antibody; Her2: human epidermal growth factor receptor 2; MFI: mean fluorescent intensity; OAA: one-armed antibody; PBS: phosphate-buffered saline; PDB: Protein Data Bank; SEC: size-exclusion chromatography; prepSEC (preparative SEC); RMSD: root-mean-square deviation; RU: resonance units; SPR: surface plasmon resonance; TAA: tumor-associated antigen; WT: wild-type.

SUBMITTER: Heinkel F 

PROVIDER: S-EPMC9645255 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature