Screening for generality in asymmetric catalysis.

ABSTRACT: Research in the field of asymmetric catalysis over the past half century has resulted in landmark advances, enabling the efficient synthesis of chiral building blocks, pharmaceuticals and natural products^1-3. A small number of asymmetric catalytic reactions have been identified that display high selectivity across a broad scope of substrates; not coincidentally, these are the reactions that have the greatest impact on how enantioenriched compounds are synthesized^4-8. We postulate that substrate generality in asymmetric catalysis is rare not simply because it is intrinsically difficult to achieve, but also because of the way chiral catalysts are identified and optimized⁹. Typical discovery campaigns rely on a single model substrate, and thus select for high

SUBMITTER: Wagen CC 

PROVIDER: S-EPMC9645431 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature