Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca²⁺ signaling.

ABSTRACT: Intracellular Ca²⁺ signaling via changes or oscillation in cytosolic Ca²⁺ concentration controls almost every aspect of cellular function and physiological processes, such as gene transcription, cell motility and proliferation, muscle contraction, and learning and memory. Two-pore channels (TPCs) are a class of eukaryotic cation channels involved in intracellular Ca²⁺ signaling, likely present in a multitude of organisms from unicellular organisms to mammals. Accumulated evidence indicates that TPCs play a critical role in Ca²⁺ mobilization from intracellular stores mediated by the second messenger molecule, nicotinic acid adenine dinucleotide phosphate (NAADP). In recent years, significant progress has been made regarding our understanding of th

SUBMITTER: Shah KR 

PROVIDER: S-EPMC9645597 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature