E-cigarette aerosol exposure of pulmonary surfactant impairs its surface tension reducing function.

ABSTRACT:

Introduction

E-cigarette (EC) and vaping use continue to remain popular amongst teenage and young adult populations, despite several reports of vaping associated lung injury. One of the first compounds that EC aerosols comes into contact within the lungs during a deep inhalation is pulmonary surfactant. Impairment of surfactant's critical surface tension reducing activity can contribute to lung dysfunction. Currently, information on how EC aerosols impacts pulmonary surfactant remains limited. We hypothesized that exposure to EC aerosol impairs the surface tension reducing ability of surfactant.

Methods

Bovine Lipid Extract Surfactant (BLES) was used as a model surfactant in a direct exposure syringe system. BLES (2ml) was placed in a syringe (30ml) attached to an EC. The ge

SUBMITTER: Graham E 

PROVIDER: S-EPMC9645651 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature