Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments.

ABSTRACT: The development of human microbiome has collectively correlated the sophisticated interactions between Fusobacterium nucleatum and colorectal cancers (CRCs). However, the treatment of CRC via disruption of gastrointestinal flora remains less explored. Aiming at the up-regulated activity of nitroreductase in F. nucleatum-infected tumors, here, we developed the nitroreductase-instructed supramolecular self-assembly. The designed assembly precursors underwent enzymatic transformation to form assemblies, which agglutinated F. nucleatum and eradicated the targeted bacteria. These assemblies with anti-F. nucleatum activity could further alleviate the bacteria-induced drug resistance effect, thus sensitizing CRC cells against chemo-drugs. Eventually, in mice bearing

SUBMITTER: Chen J 

PROVIDER: S-EPMC9645719 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature