Clinical significance of MMP-9 overexpression in endometrial cancer: A PRISMA-compliant meta-analysis.

ABSTRACT:

Objective

Several studies have found that MMP-9, one of the extracellular matrix-degrading proteinases, was involved in EC's (endometrial cancer) clinical progression and prognosis. However, the results involving the associations of MMP-9 expression with risk, clinical features and prognosis of EC were conflicting. Therefore, we performed a systematic review and meta-analysis to clarify the correlation of MMP-9 expression with EC.

Methods

Relative studies involving the associations between MMP-9 expression and EC were retrieved from PubMed, Embase, Web of Science and CNKI (China National Knowledge Infrastructure) electronic databases. OR (odds ratio) with 95% CI (confidence interval) was applied to evaluate the associations of MMP-9 expression with risk and clinical features

SUBMITTER: Li X 

PROVIDER: S-EPMC9645803 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature