Porphyrin-lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy.

ABSTRACT: Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focused primarily on photothermal therapy (PTT) and suggested that PSs require target-triggered activation for use as photodynamic therapy (PDT) sensitizers. Here, athymic nude mice bearing subcutaneous A549 human lung tumors were randomized into treatment and control groups: PS-PDT at various doses, PS-only and no treatment negative controls, as well as positive controls using the clinical photosensitizer Photofrin. Animals wer

SUBMITTER: Guidolin K 

PROVIDER: S-EPMC9646248 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature