Comparison of 1-h with 3-h planar ^99mTc-pyrophosphate scintigraphy in patients with suspected transthyretin cardiac amyloidosis using SPECT as a reference standard.

ABSTRACT:

Objectives

The purpose of this study was to examine the diagnostic value of planar ^99mTc-pyrophosphate (PYP) imaging at 1 and 3 h after tracer administration in patients with suspected transthyretin cardiac amyloidosis (ATTR-CA) using SPECT as a reference standard. We also tested whether blood pool activity of PYP is associated with renal dysfunction.

Methods

PYP images of 109 consecutive patients with suspected ATTR-CA were retrospectively reviewed. The myocardial PYP uptake was visually graded on a scale of 0 to 3 and quantified with the heart-to-contralateral (H/CL) ratio in accordance with the current expert consensus recommendations. The diagnostic value of planar images for identifying positive PYP SPECT was assessed by a receiver-operating characteristic cu

SUBMITTER: Saitou T 

PROVIDER: S-EPMC9646466 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature