Integrated analysis reveals effects of bioactive ingredients from <i>Limonium Sinense</i> (Girard) Kuntze on hypoxia-inducible factor (HIF) activation.

ABSTRACT: Limonium Sinense (Girard) Kuntze is a traditional Chinese medicinal herb, showing blood replenishment, anti-tumour, anti-hepatitis, and immunomodulation activities amongst others. However, the mechanism of its pharmacological activities remains largely unknown. Here, we investigated the effects of bioactive ingredients from Limonium Sinense using an integrated approach. Water extracts from Limonium Sinense (LSW) showed a strong growth inhibitory effect on multiple cells in both 2D and 3D cultures. Global transcriptomic profiling and further connectivity map (CMap) analysis identified several similarly acting therapeutic candidates, including Tubulin inhibitors and hypoxia-inducible factor (HIF) modulators. The effect of LSW on the cell cycle was verified with flow cyto

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9646520 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature