External validation of pulmonary radiotherapy toxicity models for ultracentral lung tumors.

ABSTRACT:

Introduction

Pulmonary toxicity is dose-limiting in stereotactic body radiation therapy (SBRT) for tumors that abut the proximal bronchial tree (PBT), esophagus, or other mediastinal structures. In this work we explored published models of pulmonary toxicity following SBRT for such ultracentral tumors in an independent cohort of patients.

Methods

The PubMed database was searched for pulmonary toxicity models. Identified models were tested in a cohort of patients with ultracentral lung tumors treated between 2008 and 2017 at one large center (N = 88). This cohort included 60 % primary and 40 % metastatic tumors treated to 45 Gy in 5 fractions (fx), 50 Gy in 5 fx, 60 Gy in 8 fx, or 60 Gy in 15 fx prescribed as 100 % dose to PTV.

Results

Seven published NTCP models from

SUBMITTER: Chen I 

PROVIDER: S-EPMC9646645 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature