RNA m⁵C regulator-mediated modification patterns and the cross-talk between tumor microenvironment infiltration in gastric cancer.

ABSTRACT: The effect of immunotherapy strategy has been affirmed in the treatment of various tumors. Nevertheless, the latent role of RNA 5-methylcytosine (m⁵C) modification in gastric cancer (GC) tumor microenvironment (TME) cell infiltration is still unclear. We systematically explore the m⁵C modification patterns of 2,122 GC patients from GEO and TCGA databases by 16 m⁵C regulators and related these patterns to TME characteristics. LASSO Cox regression was employed to construct the m⁵Cscore based on the expression of regulators and DEGs, which was used to evaluate the prognosis. All the GC patients were divided into three m⁵C modification clusters with distinct gene expression characteristics and TME patterns. GSVA, ssGSEA, and TME cell infil

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9646743 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature