Dataset Information

Exposure to ambient gaseous pollutant and daily hospitalizations for Sjogren's syndrome in Hefei: A time-series study.

ABSTRACT:

Objective

Increasing evidence suggested that gaseous pollutants were associated with the development of autoimmune diseases, while there were few studies on the association between gaseous pollutants and Sjögren's syndrome (SS). This study sought to assess the relationship between exposure to several gaseous pollutants and the hospitalizations for SS.

Methods

The data regarding SS hospitalizations, gaseous pollutants, and meteorological factors in Hefei from 2016 to 2021 were collected. A distributed lag non-linear model combined with a generalized linear model were adopted to analyze the association between gaseous pollutants and SS hospitalizations, and stratified analyses were also conducted.

Results

We detected significant associations between gaseous pollutants (NO₂, SO₂, O₃, CO) and SS hospitalizations. Exposure to NO₂ was linked with the elevated risk of hospitalizations for SS (RR=1.026, lag1 day). A positive correlation between CO exposure and hospitalizations for SS was found (RR=1.144, lag2 day). In contrast, exposure to SO₂, O₃ was respectively related to the decreased risk of hospitalizations for SS (SO₂: RR=0.897, lag14 day; O₃: RR=0.992, lag9 day). Stratified analyses found that female patients were more vulnerable to these gaseous pollutants. SS patients ≥ 65 years were more susceptible to NO₂, CO exposure, and younger patients were more vulnerable to O₃ exposure. In addition, exposure to O₃, CO in cold season were more likely to affect hospitalizations for SS.

Conclusion

Our results demonstrated a significant association between exposure to NO₂, CO and elevated risk of hospitalizations for SS, and SO₂, O₃ exposure might be linked to reduced risk of SS hospitalizations.

SUBMITTER: Zhang TP

PROVIDER: S-EPMC9646840 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Exposure to ambient gaseous pollutant and daily hospitalizations for Sjögren's syndrome in Hefei: A time-series study.

Zhang Tian-Ping TP Wang Li-Jun LJ Wang Shan S Wang Ping P Zhou Xiao-Hui XH Wang Li L Yang Chun-Mei CM Li Xiao-Mei XM

Frontiers in immunology 20221027

<h4>Objective</h4>Increasing evidence suggested that gaseous pollutants were associated with the development of autoimmune diseases, while there were few studies on the association between gaseous pollutants and Sjögren's syndrome (SS). This study sought to assess the relationship between exposure to several gaseous pollutants and the hospitalizations for SS.<h4>Methods</h4>The data regarding SS hospitalizations, gaseous pollutants, and meteorological factors in Hefei from 2016 to 2021 were coll ...[more]

PMID: 36389841

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