Ontology highlight
ABSTRACT:
SUBMITTER: Tian J
PROVIDER: S-EPMC9646987 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Tian Jiangfang J Lin Zhen Z Chen Yueyun Y Fu Yang Y Ding Zhenyu Z
Frontiers in oncology 20221027
Mesenchymal-epithelial transition (MET) exon 14 skipping mutation (METex14) is a low-frequency driver mutation in metastatic non-small cell lung cancer (NSCLC) (3%-4%) and is associated with a poor prognosis. With the advent of selective MET inhibitors such as capmatinib, tepotinib, and savolitinib, the outcome for these patients was significantly improved. Here, we report a 76-year-old male patient with marginally resectable stage IIIB lung adenocarcinoma harboring METex14 who was successfully ...[more]