Assessing Donor Liver Quality and Restoring Graft Function in the Era of Extended Criteria Donors.

ABSTRACT: Liver transplantation (LT) is the final treatment option for patients with end-stage liver disease. The increasing donor shortage results in the wide usage of grafts from extended criteria donors across the world. Using such grafts is associated with the elevated incidences of post-transplant complications including initial nonfunction and ischemic biliary tract diseases, which significantly reduce recipient survival. Although several clinical factors have been demonstrated to impact donor liver quality, accurate, comprehensive, and effective assessment systems to guide decision-making for organ usage, restoration or discard are lacking. In addition, the development of biochemical technologies and bioinformatic analysis in recent years helps us better understand graft injury during the per

SUBMITTER: Lin Y 

PROVIDER: S-EPMC9647107 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature