Ontology highlight
ABSTRACT:
SUBMITTER: Du G
PROVIDER: S-EPMC9647118 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Du Gan G Yang Ruizhe R Qiu Jianguo J Xia Jie J
Journal of clinical and translational hepatology 20220913 1
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and a leading cause of cancer-related mortality worldwide, but its pathogenesis remains largely unknown. Nevertheless, genomic instability has been recognized as one of the facilitating characteristics of cancer hallmarks that expedites the acquisition of genetic diversity. Genomic instability is associated with a greater tendency to accumulate DNA damage and tumor-specific DNA repair defects, which gives rise to gene m ...[more]