Single-cell RNA sequencing reveals TCR⁺ macrophages in HPV-related head and neck squamous cell carcinoma.

ABSTRACT: The prognosis of human papillomavirus (HPV)-infected head and neck squamous cell carcinoma (HNSCC) is often better than that of HPV^- cancer, which is possibly caused by the differences in their immune microenvironments. The contribution of macrophage, as a principal innate immune cell, to this phenomenon is still unclear. In this study, a single-cell atlas of 4,388 high-quality macrophages from 18 HPV^- and 8 HPV⁺ HNSCC patients was constructed with single-cell RNA sequencing data. Eight macrophage subsets were identified from HNSCC, whereas their functional properties and developmental trajectory were delineated based on HPV status. Our results demonstrated that macrophages in HPV⁺ HNSCC exhibit stronger phagocytic ability, although the infiltrat

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9647120 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature