Effects of Hst3p inhibition in Candida albicans: a genome-wide H3K56 acetylation analysis.

ABSTRACT: Candida spp. represent the third most frequent worldwide cause of infection in Intensive Care Units with a mortality rate of almost 40%. The classes of antifungals currently available include azoles, polyenes, echinocandins, pyrimidine derivatives, and allylamines. However, the therapeutical options for the treatment of candidiasis are drastically reduced by the increasing antifungal resistance. The growing need for a more targeted antifungal therapy is limited by the concern of finding molecules that specifically recognize the microbial cell without damaging the host. Epigenetic writers and erasers have emerged as promising targets in different contexts, including the treatment of fungal infections. In C. albicans, Hst3p, a sirtuin that deacetylates H3K56ac, represents an at

SUBMITTER: Conte M 

PROVIDER: S-EPMC9647175 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature