Multiscale modelling of claudin-based assemblies: A magnifying glass for novel structures of biological interfaces.

ABSTRACT: Claudins (Cldns) define a family of transmembrane proteins that are the major determinants of the tight junction integrity and tissue selectivity. They promote the formation of either barriers or ion-selective channels at the interface between two facing cells, across the paracellular space. Multiple Cldn subunits form complexes that include cis- (intracellular) interactions along the membrane of a single cell and trans- (intercellular) interactions across adjacent cells. The first description of Cldn assemblies was provided by electron microscopy, while electrophysiology, mutagenesis and cell biology experiments addressed the functional role of different Cldn homologs. However, the investigation of the molecular details of Cldn subunits and complexes are hampered by the lack

SUBMITTER: Berselli A 

PROVIDER: S-EPMC9647347 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature