Characterizing the role of the immune microenvironment in multiple myeloma progression at a single-cell level.

ABSTRACT: Early alterations within the bone marrow microenvironment that contribute to the progression of multiple myeloma (MM) from its precursor stages could be the key to identifying novel therapeutic approaches. However, the intrinsic variability in cellular populations between patients and the differences in sample processing and analysis methods have made it difficult to identify consistent changes between data sets. Here, we used single-cell RNA sequencing of bone marrow cells from precursor stages, monoclonal gammopathy of unknown significance, smoldering MM, and newly diagnosed MM and analyzed our data in combination with a previously published data set that used a similar patient population and sample processing. Despite the vast interpatient heterogeneity, some alterations were consistent

SUBMITTER: Schinke C 

PROVIDER: S-EPMC9647426 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature