Ficus crocata leaf extracts decrease the proliferation and invasiveness of breast cancer cells.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype due to its greater invasive capacity and non-response to hormone therapy. Several species of the Ficus genus have been used as an alternative to traditional medicine against malignant diseases. Previously, leaf extracts from Ficus crocata (Miq.) Mart. ex Miq. (F. crocata) showed antiproliferative activity in vitro against breast and cervical tumor cells without having a cytotoxic effect on non-tumor cell lines. The purpose of the study was to evaluate the effect of hexane (Hex-EFc), dichloromethane (Dic-EFc), and acetone (Ace-EFc) extracts from F. crocata on the proliferative and invasive capacity of breast cancer cells MCF-7 and MDA-MB-231.

Materials and methods

The phytochemical

SUBMITTER: Cayetano-Salazar L 

PROVIDER: S-EPMC9647462 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature