The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial.

ABSTRACT:

Background

According to the cognitive neuropsychological model, antidepressants reduce symptoms of depression and anxiety by increasing positive relative to negative information processing. Most studies of whether antidepressants alter emotional processing use small samples of healthy individuals, which lead to low statistical power and selection bias and are difficult to generalise to clinical practice. We tested whether the selective serotonin reuptake inhibitor (SSRI) sertraline altered recall of positive and negative information in a large randomised controlled trial (RCT) of patients with depressive symptoms recruited from primary care.

Methods

The PANDA trial was a pragmatic multicentre double-blind RCT comparing sertraline with placebo. Memory for personality descript

SUBMITTER: Ahmed N 

PROVIDER: S-EPMC9647512 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature