Enteropathogen Changes After Rotavirus Vaccine Scale-up.

ABSTRACT:

Objectives

To inform next steps in pediatric diarrhea burden reduction by understanding the shifting enteropathogen landscape after rotavirus vaccine implementation.

Methods

We conducted a case-control study of 1788 medically attended children younger than 5 years, with and without gastroenteritis, after universal rotavirus vaccine implementation in Peru. We tested case and control stools for 5 viruses, 19 bacteria, and parasites; calculated coinfection-adjusted attributable fractions (AFs) to determine pathogen-specific burdens; and evaluated pathogen-specific gastroenteritis severity using Clark and Vesikari scales.

Results

Six pathogens were independently positively associated with gastroenteritis: norovirus genogroup II (GII) (AF 29.1, 95% confidence interval [CI]

SUBMITTER: Ballard SB 

PROVIDER: S-EPMC9647525 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature