Shared functional impairment in the prefrontal cortex affects symptom severity across psychiatric disorders.

ABSTRACT:

Background

The prefrontal deficits in psychiatric disorders have been investigated using functional neuroimaging tools; however, no studies have tested the related characteristics across psychiatric disorders considering various demographic and clinical confounders.

Methods

We analyzed 1558 functional brain measurements using a functional near-infrared spectroscopy during a verbal fluency task from 1200 participants with three disease spectra [196 schizophrenia, 189 bipolar disorder (BPD), and 394 major depressive disorder (MDD)] and 369 healthy controls along with demographic characteristics (age, gender, premorbid IQ, and handedness), task performance during the measurements, clinical assessments, and medication equivalent doses (chlorpromazine, diazepam, biperiden, and im

SUBMITTER: Koike S 

PROVIDER: S-EPMC9647535 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature