Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia.

ABSTRACT:

Background

Newborn infants affected by hypoxic-ischemic encephalopathy (HIE) undergo therapeutic hypothermia. As this treatment seems to be associated with pain, and intensive and invasive care is needed, pharmacological interventions are often used. Moreover, painful procedures in the newborn period can affect pain responses later in life, impair brain development, and possibly have a long-term negative impact on neurodevelopment and quality of life.

Objectives

To determine the effects of pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia. Primary outcomes were analgesia and sedation, and all-cause mortality to discharge.

Search methods

We searched CENTRAL, PubMed, CINAHL (Cumulative Index to Nursing a

SUBMITTER: Backe P 

PROVIDER: S-EPMC9647594 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature