G Protein Coupled Receptors Potentially Involved in Oligodendrogenesis: A Gene Expression Analysis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by infiltration of inflammatory leukocytes to the CNS followed by oligodendrocyte cell death, myelin sheath destruction, and axonal injury. A logical incidence occurring after demyelination is remyelination. G-protein coupled receptors (GPCRs) activate internal signal transduction cascades through binding to different ligands. This family of receptors are targeted by more than 40% of currently marketed drugs. GPCRs can be successfully targeted for induction of remyelination. GPCRs highly enriched in oligodendrocyte progenitor cells compared to oligodendrocytes are proposed to hamper oligodendrocyte differentiation and therefore their inhibition might induce remyelinatio

SUBMITTER: Karami N 

PROVIDER: S-EPMC9647597 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature