Expression and Prognostic Value of RAD51 in Adenocarcinoma at the Gastroesophageal Junction.

ABSTRACT:

Background

The RAD51 recombinase is involved in homologous recombination and DNA repair. However, the association of RAD51 with the prognosis of adenocarcinoma at the gastroesophageal junction (ACGEJ) is not clear. We aimed to investigate the association of RAD51 with ACGEJ prognosis.

Methods

The difference in the expression level of RAD51 between ACGEJ tumors and control tissues in the microarray datasets (GSE159721, GSE74553, and GSE96669) were compared. The online Kaplan-Meier plotter survival analysis and meta-analysis were used to analyze the association of RAD51 with overall survival in pan-cancers. MiRNAs targeting RAD51 were identified and their expression profiles in ACGEJ tumors were analyzed. Functional enrichment analysis

SUBMITTER: Redati D 

PROVIDER: S-EPMC9647605 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature