New multienzymatic complex formed between human cathepsin D and snake venom phospholipase A₂.

ABSTRACT:

Background

Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, and apoptosis. The overexpression and hypersecretion of CatD have been correlated with cancer aggressiveness and tumor progression, stimulating cancer cell proliferation, fibroblast growth, and angiogenesis. In addition, some studies report its participation in neurodegenerative diseases and inflammatory processes. In this regard, the search for new inhibitors from natural products could be an alternative against the harmful effects of this enzyme.

Methods

An investigation was

SUBMITTER: Moraes JDN 

PROVIDER: S-EPMC9647731 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature