Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension.

ABSTRACT:

Background

Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced hypertension is sodium-sensitive in animal studies. Therefore, the efficacy of dietary sodium restriction (DSR) to prevent VEGFI-induced hypertension in cancer patients was studied.

Methods

Cancer patients with VEGFI-induced hypertension (day mean >135/85 mmHg or a rise in systolic and/or diastolic BP ≥ 20 mmHg) were treated with DSR (aiming at <4 g salt/day). The primary endpoint was the difference in daytime mean arterial blood pressure (MAP) increase between the treatment cycle with and without DSR.

Results

During the first VEGFI treatment cycle without DSR, mean daytime MAP increased from 95 to 110 mmHg. During the subseq

SUBMITTER: van Doorn L 

PROVIDER: S-EPMC9647750 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature