Predictors of Disease Activity and Worsening in Relapsing-Remitting Multiple Sclerosis.

ABSTRACT:

Background and objectives

Disease activity in multiple sclerosis (MS) is highly variable, and there are limited prospective studies on predictors of disease outcomes. The goal of this study is to identify and assess patient characteristics in MS that predict disease activity and worsening.

Methods

The study population consisted of a prospective cohort of 1,008 participants with relapsing-remitting onset MS enrolled in the CombiRx trial. Cox regression analysis was used to determine hazard ratio (HR) associations between baseline (BL) demographics, clinical history, MRI metrics, and treatment with outcomes of time to first new disease activity over up to 7 years of follow-up including relapse, MRI activity, and disease worsening.

Results

One thousand eight participants

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9647819 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature