Prevalence of hepatotoxicity among HIV-infected patients in Ethiopia: a systematic review and meta-analysis.

ABSTRACT:

Background

Globally, the human immunodeficiency virus has been recognized as a major public health concern. The direct toxicity of antiretroviral medicines or their active metabolites causes liver cell destruction by different mechanisms, inducing immune-mediated inflammation, oxidative stress, and other mechanisms. On the other hand, the virus itself also produces hepatotoxicity. Therefore, this systematic review and meta-analysis aimed to assess the pooled prevalence of hepatotoxicity among HIV-infected patients in Ethiopia.

Methods

PubMed, Science Direct, Cochrane Library, Web of Science, and ResearchGate databases were used to find relevant articles. As well, various professional associations were searched to retrieve grey literature. The Newcastle-Ottawa Quality Assessm

SUBMITTER: Mohammed O 

PROVIDER: S-EPMC9647905 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature