Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident cardiovascular disease.

ABSTRACT:

Background

Risk profiles for premature cardiovascular disease (CVD) are unclear. This study aimed to examine baseline risk profiles for incident CVD by age at onset in Chinese population.

Methods

A total of 97,841 participants without CVD were enrolled from the Kailuan cohort study. Four age groups were examined (< 55, 55 to < 65, 65 to < 75, and ≥ 75 years) for CVD onset. Risk profiles included clinical, lipid, metabolic, and inflammatory risk factors and biomarkers.

Results

Of the clinical factors, diabetes was associated with the highest relative risk for incident CVD in participants younger than 55 years (sub-distributional hazard ratio [sHR], 4.08; 95% confidence interval [CI], 3.47-4.80). Risk factors that were also noted for CVD onset in participants y

SUBMITTER: Tian X 

PROVIDER: S-EPMC9647925 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature