The clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 articles incorporating 12,120 patients.

ABSTRACT:

Objective

This study was designed to investigate the frequency and clinicopathological characteristics of POLE-mutated/ultramutated (POLEmut) in endometrial carcinoma (EC) and assess the prognostic values of POLE status.

Methods

Electronic databases were screened to identify relevant studies. Meta-analysis was used to yield the pooled frequency of POLEmut and prognostic parameters by 95% confidence interval (CI), odd ratio (OR), and hazard ratio (HR).

Results

Totally, 12,120 EC patients from 49 studies were included. The pooled frequency of POLEmut was 7.95% (95% CI: 6.52-9.51%) in EC, 7.95% (95% CI: 6.55-9.46%) in endometrioid endometrial carcinoma, and 4.45% (95% CI: 2.63-6.61%) in nonendometrioid endometrial carcinoma. A higher expression occurred in grade 3 (OR = 

SUBMITTER: Wu Q 

PROVIDER: S-EPMC9647950 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature