Molecular, cellular and neurological consequences of infection by the neglected human pathogen Nocardia.

ABSTRACT:

Background

Nocardia is a facultative intracellular pathogen that infects the lungs and brains of immunocompromised patients with consequences that can be fatal. The incidence of such infections is rising, immunocompetent individuals are also being infected, and there is a need to learn more about this neglected bacterial pathogen and the interaction with its human host.

Results

We have applied dual RNA-seq to assess the global transcriptome changes that occur simultaneously in Nocardia farcinica (N. farcinica) and infected human epithelial alveolar host cells, and have tested a series of mutants in this in vitro system to identify candidate determinants of virulence. Using a mouse model, we revealed the profiles of inflammation-related factors in the lung after intranasal in

SUBMITTER: Ji X 

PROVIDER: S-EPMC9647956 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature