A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationships.

ABSTRACT:

Background

Chromatin contacts are essential for gene-expression regulation; however, obtaining a high-resolution genome-wide chromatin contact map is still prohibitively expensive owing to large genome sizes and the quadratic scale of pairwise data. Chromosome conformation capture (3C)-based methods such as Hi-C have been extensively used to obtain chromatin contacts. However, since the sparsity of these maps increases with an increase in genomic distance between contacts, long-range or trans-chromatin contacts are especially challenging to sample.

Results

Here, we create a high-density reference genome-wide chromatin contact map using a meta-analytic approach. We integrate 3600 human, 6700 mouse, and 500 fly Hi-C experiments to create species-specific meta-Hi-C chromatin co

SUBMITTER: Lohia R 

PROVIDER: S-EPMC9647974 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature