Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network.

ABSTRACT:

Background

Schema, a concept from cognitive psychology used to explain how new information is integrated with previous experience, is a framework of acquired knowledge within associative network structures as biological correlate, which allows new relevant information to be quickly assimilated by parallel cortical encoding in the hippocampus (HPC) and cortex. Previous work demonstrated that myelin generation in the anterior cingulate cortex (ACC) plays a critical role for dynamic paired association (PA) learning and consolidation, while astrocytes in ACC play a vital role in cognitive decision-making. However, circuit components and mechanism involving HPC-anterior cingulate cortex (ACC) during schema formation remain uncertain. Moreover, the correlation between HPC-ACC circuit and

SUBMITTER: Liu S 

PROVIDER: S-EPMC9648012 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature