Aging and white matter microstructure and macrostructure: a longitudinal multi-site diffusion MRI study of 1218 participants.

ABSTRACT: Quantifying the microstructural and macrostructural geometrical features of the human brain's connections is necessary for understanding normal aging and disease. Here, we examine brain white matter diffusion magnetic resonance imaging data from one cross-sectional and two longitudinal data sets totaling in 1218 subjects and 2459 sessions of people aged 50-97 years. Data was drawn from well-established cohorts, including the Baltimore Longitudinal Study of Aging data set, Cambridge Centre for Ageing Neuroscience data set, and the Vanderbilt Memory & Aging Project. Quantifying 4 microstructural features and, for the first time, 11 macrostructure-based features of volume, area, and length across 120 white matter pathways, we apply linear mixed effect modeling to investigate changes in pathwa

SUBMITTER: Schilling KG 

PROVIDER: S-EPMC9648053 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature