Advances in the pharmacological management of acute myeloid leukemia in adults.

ABSTRACT:

Introduction

With advances in molecular medicine and precision approaches, there has been significant improvement in the treatment of acute myeloid leukemia (AML) in recent years. This reflects better understanding of molecular and metabolic pathways in leukemia cells, including BCL2 upregulation that prevents apoptosis, FLT3 tyrosine kinase activating mutations that allow uncontrolled proliferation, and IDH mutations that result in differentiation block.

Areas covered

We performed a compressive review of important pre-clinical studies in AML that involve major molecular and metabolic pathways in AML, and we discussed standard therapeutic modalities and ongoing clinical trials for patients with AML, as well as an overall update of recent efforts in this area.

Expert opini

SUBMITTER: Numan Y 

PROVIDER: S-EPMC9648129 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature