Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers.

ABSTRACT: The objective of this study was to determine the effects of the OATP inhibitor rifampin on pharmacokinetic of Biopharmaceutics Drug Disposition Classification System Class 1 compound fluvastatin. A crossover study was carried out in 10 healthy subjects who were randomized to 2 phases to receive fluvastatin 20 mg orally alone and following a 30-minute 600 mg i.v. infusion of rifampin. The results demonstrated that i.v. rifampin increased the mean area under the plasma fluvastatin concentration-time curve (AUC_0-∞ ) by 255%, mean peak plasma concentration (C_max ) by 254%, decreased oral volume of distribution by 71%, whereas the mean elimination terminal half-life (T_1/2 ), mean absorption time (MAT), and time to peak concentration (T_peak ) of fluvas

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC9648157 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature