Gut microbiota display alternative profiles in patients with early-onset colorectal cancer.

ABSTRACT:

Background

The incidence of early-onset colorectal cancer (EOCRC) is increasing worldwide. This study aimed to explore whether there is an alternative gut microbiota profile in patients with early-onset colorectal cancer.

Methods

A total of 24 patients with EOCRC, 43 patients with late-onset colorectal cancer and 31 young volunteers were included in this study. The diversity of their fecal bacteria was explored using 16S ribosomal RNA gene sequencing. Cluster of ortholog genes (COG) functional annotation and Kyoto encyclopedia of genes and genomes (KEGG) were used to detect enrichment pathways among the three groups.

Results

Community separations were observed among the three groups. The Shannon index of the EOCRC group was significantly lower than the LOCRC group (P=

SUBMITTER: Xiong H 

PROVIDER: S-EPMC9648186 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature