Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma.

ABSTRACT:

Background

Despite integrin being highlighted as a stiffness-sensor molecule in matrix stiffness-driven angiogenesis, other stiffness-sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma (HCC) remain obscure. Here, we explored the interplay between Piezo1 and integrin β1 in the mechanosensory pathway and their effects on HCC angiogenesis to better understand matrix stiffness-induced angiogenesis.

Methods

The role of Piezo1 in matrix stiffness-induced angiogenesis was investigated using orthotopic liver cancer SD rat models with high liver stiffness background, and its clinical significance was evaluated in human HCC tissues. Matrix stiffness-mediated Piezo1 upregulation and activation were assayed using an in vitro fibronecti

SUBMITTER: Li M 

PROVIDER: S-EPMC9648387 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature