CD19⁺CD24^hiCD38^hi regulatory B cells deficiency revealed severity and poor prognosis in patients with sepsis.

ABSTRACT:

Background

Sepsis still remains a major challenge in intensive care medicine with unacceptably high mortality among patients with septic shock. Due to current limitations of human CD19⁺CD24^hiCD38^hi Breg cells (Bregs) studies among sepsis, here, we tried to evaluate Bregs in severity and prognostic value in patients with sepsis.

Methods

Peripheral blood from 58 patients with sepsis and 22 healthy controls was analyzed using flow cytometry to evaluate the frequency and number of Bregs. All cases were divided into non-survived or survived group after 28 days followed up. Spearman's correlation analysis was performed on Bregs frequency and clinical indices. The area under the curve was acquired using the receiver operating characteristic analysis

SUBMITTER: Wang C 

PROVIDER: S-EPMC9648441 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature