Calpain-mediated proteolysis as driver and modulator of polyglutamine toxicity.

ABSTRACT: Among posttranslational modifications, directed proteolytic processes have the strongest impact on protein integrity. They are executed by a variety of cellular machineries and lead to a wide range of molecular consequences. Compared to other forms of proteolytic enzymes, the class of calcium-activated calpains is considered as modulator proteases due to their limited proteolytic activity, which changes the structure and function of their target substrates. In the context of neurodegeneration and - in particular - polyglutamine disorders, proteolytic events have been linked to modulatory effects on the molecular pathogenesis by generating harmful breakdown products of disease proteins. These findings led to the formulation of the toxic fragment hypothesis, and calpains appeared to b

SUBMITTER: Incebacak Eltemur RD 

PROVIDER: S-EPMC9648470 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature