Catch-enrich-release approach for amine-containing natural products.

ABSTRACT: Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.

SUBMITTER: Muller MJ 

PROVIDER: S-EPMC9648515 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature