Elevated serum globulin fraction as a biomarker of multiyear disease severity in inflammatory bowel disease.

ABSTRACT:

Background

Serum protein reflects albumin and globulin levels, both of which can be altered in inflammatory bowel disease (IBD). The implications of a high globulin fraction in IBD are unknown. We hypothesized that a high globulin fraction may function independently of albumin as a biomarker of disease severity in IBD patients over a multiyear period.

Methods

This was an observational study from a prospective IBD registry of a tertiary care center. High globulin fraction was defined as an elevated globulin level >4 g/dL. Data collected included patient demographics, medication exposures, quality-of-life scores, disease activity, emergency department visits, telephone calls, hospitalizations, and IBD-related surgeries over a 4-year period. Comparisons between patients with a

SUBMITTER: Hashash JG 

PROVIDER: S-EPMC9648529 | biostudies-literature | 2022 Nov-Dec

REPOSITORIES: biostudies-literature