Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections.

ABSTRACT:

Background

Necrotizing soft tissue infections (NSTIs) are severe diseases with high morbidity and mortality. The diagnosis is challenging. Several guidelines recommend tissue biopsies as an adjunct diagnostic in routine management, but neither biopsy sampling nor classification is standardized or validated. We studied the quality of tissue biopsy examination as part of routine diagnostics in NSTIs.

Methods

This was a retrospective cohort study of adult patients undergoing surgery due to suspected NSTIs in which tissue biopsy was taken as part of routine management. Clinical data were reviewed. The biopsies were evaluated according to a proposed histopathologic classification system and independently assessed by 2 pathologists. Interrater reliability and diagnostic accuracy w

SUBMITTER: Gundersen IM 

PROVIDER: S-EPMC9648561 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature