Factors Associated With Liver Steatosis in People With Human Immunodeficiency Virus on Contemporary Antiretroviral Therapy.

ABSTRACT:

Background

Given the impact of new antiretroviral drugs on weight and metabolic parameters, their potential contribution to the development of liver steatosis is of concern. We investigated the determinants of liver steatosis in patients on antiretroviral therapy (ART) in the Swiss HIV Cohort Study (SHCS).

Methods

Between 2019 and 2021, we measured liver stiffness and controlled attenuation parameter (CAP) using transient elastography in consecutive SHCS participants at Bern University Hospital. Individuals with viral hepatitis coinfection and pregnant women were excluded. We used multivariable logistic regression to explore factors associated with steatosis.

Results

Of 416 participants, 113 (27.2%) were female, median age was 51 years (interquartile range [IQR], 43-5

SUBMITTER: Riebensahm C 

PROVIDER: S-EPMC9648562 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature