Differential effects of an experimental model of prolonged sleep disturbance on inflammation in healthy females and males.

ABSTRACT: Sleep disturbances, including disrupted sleep and short sleep duration, are highly prevalent and are prospectively associated with an increased risk for various widespread diseases, including cardiometabolic, neurodegenerative, chronic pain, and autoimmune diseases. Systemic inflammation, which has been observed in populations experiencing sleep disturbances, may mechanistically link disturbed sleep with increased disease risks. To determine whether sleep disturbances are causally responsible for the inflammatory changes reported in population-based studies, we developed a 19-day in-hospital experimental model of prolonged sleep disturbance inducing disrupted and shortened sleep. The model included delayed sleep onset, frequent nighttime awakenings, and advanced sleep offset, interspersed

SUBMITTER: Besedovsky L 

PROVIDER: S-EPMC9648610 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature